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desethylene ciprofloxacin, hydrochloride

Names

[ CAS No. ]:
528851-31-2

[ Name ]:
desethylene ciprofloxacin, hydrochloride

[Synonym ]:
Enrofloxacin Imp. G (EP),HCl
Desethylene Ciprofloxacin,Hydrochloride
7-[(2-amino-ethyl)amino]-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-quinoline-3-carboxylic acid hydrochloride
BAY-r 3964,M1-Ciprofloxacin,7-[(2-Aminoethyl)amino]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

Biological Activity

[Description]:

Desethylene Ciprofloxacin hydrochloride is a major metabolite of Ciprofloxacin (HY-B0356). Ciprofloxacin is an orally active topoisomerase IV inhibitor. Desethylene Ciprofloxacin hydrochloride has antibacterial activity[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Šíma M, et al. Factors Affecting the Metabolic Conversion of Ciprofloxacin and Exposure to Its Main Active Metabolites in Critically Ill Patients: Population Pharmacokinetic Analysis of Desethylene Ciprofloxacin. Pharmaceutics. 2022 Aug 4;14(8):1627.  

Chemical & Physical Properties

[ Melting Point ]:
>240ºC dec.

[ Molecular Formula ]:
C15H17ClFN3O3

[ Molecular Weight ]:
341.77

[ Exact Mass ]:
341.09400

[ PSA ]:
97.35000

[ LogP ]:
3.11960

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H410

[ Precautionary Statements ]:
P273-P301 + P310-P501

[ Hazard Codes ]:
T,N

[ Risk Phrases ]:
25-50/53

[ Safety Phrases ]:
45-60-61

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds