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Violanone

Names

[ CAS No. ]:
52250-38-1

[ Name ]:
Violanone

Biological Activity

[Description]:

Violanone, an isoflavanone compound, can inhibit tubulin polymerization. Violanone also exhibits larvicidal activity against A. aegypti[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Microtubule/Tubulin[1]


[In Vitro]

Violanone inhibitS the microtubule assembly by 16%[1]. Violanone shows larvicidal activity against A. aegypti, with an LC50 of 157.55 µg/mL[2].

[References]

[1]. Deesamer S, et, al. Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri. Tetrahedron. 2007 Dec 24; 63(52): 12986-12993.

[2]. Bezerra-Silva PC, et, al. Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito. Exp Parasitol. 2015 Jun;153:160-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H16O6

[ Molecular Weight ]:
316.305

[ Storage condition ]:
2-8℃

Related Compounds