MMP13-IN-4

Names

[ CAS No. ]:
514855-02-8

[ Name ]:
MMP13-IN-4

Biological Activity

[Description]:

MMP13-IN-4 (compound 13) is a potent and selective inhibitor of MMP-13 (IC50=14.6 μM)，involved in osteoarthritis (OA)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

IC50: 91 μM (MMP-1), 99 μM (MMP-2), 68 μM (MMP-9), 14.6 μM (MMP-13), 63 μM (MMP-14)[1]


[References]

[1]. Cuffaro D, et al. Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization. Int J Mol Sci. 2023 Jul 4;24(13):11098.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H17BrN4O5

[ Molecular Weight ]:
485.29

Related Compounds

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