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514855-02-8

514855-02-8 structure

514855-02-8 structure

Name: MMP13-IN-4
Chemical Name: MMP13-IN-4
CAS Number: 514855-02-8
Molecular Formula: C₂₁H₁₇BrN₄O₅
Molecular Weight: 485.29
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2023-11-25 12:41:56
Modify Date: 2024-01-27 22:15:04
MMP13-IN-4 (compound 13) is a potent and selective inhibitor of MMP-13 (IC50=14.6 μM)，involved in osteoarthritis (OA)[1].

Name	MMP13-IN-4

Description	MMP13-IN-4 (compound 13) is a potent and selective inhibitor of MMP-13 (IC50=14.6 μM)，involved in osteoarthritis (OA)[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	IC50: 91 μM (MMP-1), 99 μM (MMP-2), 68 μM (MMP-9), 14.6 μM (MMP-13), 63 μM (MMP-14)[1]
References	[1]. Cuffaro D, et al. Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization. Int J Mol Sci. 2023 Jul 4;24(13):11098.

Molecular Formula	C₂₁H₁₇BrN₄O₅
Molecular Weight	485.29