CYCLOPENTOLATE

Names

[ CAS No. ]:
512-15-2

[ Name ]:
CYCLOPENTOLATE

[Synonym ]:
Ocu-Pentolate
Cyclogyl
Cylate
Mydrilate
2-(dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate
Cyclopentoiate
Ciclopentolato
Cyclopentolatum

Biological Activity

[Description]:

Cyclopentolate (DL-Cyclopentolate) is an Atropine-like muscarinic receptors antagonist with a pKB value of 7.8 (on the circular ciliary muscle). Cyclopentolate is an anti-muscarinic agent commonly used in the ophthalmologic practice[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR

Signaling Pathways >> GPCR/G Protein >> mAChR

Research Areas >> Neurological Disease

[In Vivo]

Survival in rats pretreated with cyclopentolate (20 mg/kg) is 90%[3].

[References]

[1]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928.

[2]. Ishikawa H, DeSantis L, Patil PN. Selectivity of muscarinic agonists including (+/-)-aceclidine and antimuscarinics on the human intraocular muscles. J Ocul Pharmacol Ther. 1998;14(4):363‐373.

[3]. Öner V, Bulut A, Öter K. The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults. Eye (Lond). 2016;30(7):925‐928.

Chemical & Physical Properties

[ Density]:
1.136g/cm3

[ Boiling Point ]:
409.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₂₅NO₃

[ Molecular Weight ]:
291.38500

[ Flash Point ]:
201.5ºC

[ Exact Mass ]:
291.18300

[ PSA ]:
49.77000

[ LogP ]:
2.18010

[ Index of Refraction ]:
1.555

MSDS

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Safety Information

[ HS Code ]:
2922509090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%