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Substance P (6-11)

Names

[ CAS No. ]:
51165-07-2

[ Name ]:
Substance P (6-11)

[Synonym ]:
substance P(6-11)
[Gln6]substance P(6-11)
glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide
SUBSTANCE P FRAGMENT 6-11)
L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
HEXA-SUBSTANCE P
SUBSTANCE-P-(-6-11) HEXA-SUBSTANCE P
H-GLN-PHE-PHE-GLY-LEU-MET-NH2
GLN-PHE-PHE-GLY-LEU-MET-NH2

Biological Activity

[Description]:

Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vitro]

Substance P(6-11) 在大鼠膀胱中刺激 [3H]-肌醇一磷酸 ([3H]-IP1) 的形成，EC50 值为 4 nM。

[In Vivo]

Substance P (6-11) (0.1-10 nM) 以剂量依赖的方式抑制大鼠胰腺分泌胰岛素和胰高血糖素。相反，在犬胰腺中，Substance P (6-11) (1-10 nM) 会增强胰岛素、胰高血糖素和生长抑素的释放[2]。

[References]

[1]. Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51.  

[2]. Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000.  

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
1198.9ºC at 760 mmHg

[ Molecular Formula ]:
C36H52N8O7S

[ Molecular Weight ]:
740.91200

[ Flash Point ]:
678.9ºC

[ Exact Mass ]:
740.36800

[ PSA ]:
283.00000

[ LogP ]:
3.45990

[ Index of Refraction ]:
1.579

Related Compounds