2-Hydroxy Ibuprofen

Names

[ Name ]:
2-Hydroxy Ibuprofen

[Synonym ]:
2-[4-(2-Hydroxy-2-methylpropyl)phenyl]propionic acid
2-[4-(2-hydroxy-2-methylpropyl)phenyl]propanoic acid
2-Hydroxyibuprofen
Ibuprofen Impurity 19

Biological Activity

[Description]:

2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[References]

[1]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7.

Chemical & Physical Properties

[ Density]:
1.125 g/cm3

[ Boiling Point ]:
369.4ºC at 760 mmHg

[ Melting Point ]:
120-122ºC

[ Molecular Formula ]:
C₁₃H₁₈O₃

[ Molecular Weight ]:
222.28000

[ Exact Mass ]:
222.12600

[ PSA ]:
57.53000

[ LogP ]:
2.18810

[ Index of Refraction ]:
1.543

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Related Compounds

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