(+)-Metamfetamine hydrochloride

Names

[ CAS No. ]:
51-57-0

[ Name ]:
(+)-Metamfetamine hydrochloride

[Synonym ]:
d-desoxyephedrine hydrochloride
adipex
d-Methylamphetamine hydrochloride
(+)-N,α-dimethylphenethylamine hydrochloride
(+)-Methamphetamine chloride
Benzeneethanamine, N,α-dimethyl-, (αS)-, hydrochloride (1:1)
d-N-Methyl-b-phenylisopropylamine Hydrochloride
(+)METHAMPHETAMINE HYDROCHLORIDE
Phenethylamine, N,α-dimethyl-, hydrochloride, (S)-(+)-
doxyfed
Hiropon
DOE
Methylisomyn
Semoxydrine
Madrine
(aS)-N,a-Dimethylbenzeneethanamine Hydrochloride
Destim
METH
TONEDRON
(S)-(+)-N,a-Dimethylphenethylamine Hydrochloride
D-N,α-Dimethylphenethylamine hydrochloride
metamphetamine*HCl
Isophen
Benzeneethanamine, N,α-dimethyl-, hydrochloride, (S)- (9CI)
S-(+)-Methamphetamine hydrochloride
(+)-N-Methylamphetamine hydrochloride
Doxephrin
(2S)-N-Methyl-1-phenylpropan-2-amine hydrochloride (1:1)
D-N-Methyl-β-phenylisopropylamine hydrochloride
(S)-(+)-methamphetamine hydrochloride
Desoxyn
methedrine
benzeneethanamine, N,α-dimethyl-, (αS)-, hydrochloride
Desoxo 5
(2S)-N-methyl-1-phenylpropan-2-amine hydrochloride
Syndrox
Metamphetamine hydrochloride
Pervitin
(2S)-N-méthyl-1-phénylpropan-2-amine chlorhydrate
(+)-N,a-Dimethylphenethylamine Hydrochloride
Metamfetamine hydrochloride
Benzeneethanamine, N,α-dimethyl-, hydrochloride, (S)-
(+)-(S)-methylamphetamine hydrochloride
dextim
(+)-Methylamphetamine hydrochloride
(S)-N,a-Dimethylbenzeneethanamine Hydrochloride
deofed
gerovit
Desfedrin
d-N,a-Dimethylphenethylamine Hydrochloride
(+)-METHAMPHETAMINE HYDROCHLORIDE
Methamphetamine hydrochloride
Desoxyfed
d-Methamphetamine hydrochloride
(2S)-N-Methyl-1-phenylpropan-2-aminhydrochlorid
(2S)-N-Methyl-1-phenyl-2-propanamine hydrochloride (1:1)
dexoval

Chemical & Physical Properties

[ Boiling Point ]:
215.5ºC at 760mmHg

[ Melting Point ]:
166-168ºC

[ Molecular Formula ]:
C₁₀H₁₆ClN

[ Molecular Weight ]:
185.694

[ Flash Point ]:
86.8ºC

[ Exact Mass ]:
185.097122

[ PSA ]:
12.03000

[ LogP ]:
3.02990

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SH5455000

CHEMICAL NAME :: Phenethylamine, N,alpha-dimethyl-, hydrochloride, (S)-(+)-

CAS REGISTRY NUMBER :: 51-57-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C10-H15-N.Cl-H

MOLECULAR WEIGHT :: 185.72

WISWESSER LINE NOTATION :: 1MY1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10930 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 253,466,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,346,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7560 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,214,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02170

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 84,351,1954 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg female 1-21 day(s) after conception lactating female 19 day(s) post-birth

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis

REFERENCE :: EAGRDS Experimental Aging Research. (Beech Hill Pub. Co., POB 136, Southwest Harbor, ME 04679) V.1- 1975- Volume(issue)/page/year: 5,509,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 792 mg/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: JONRA9 Journal of Neurochemistry. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1956- Volume(issue)/page/year: 20,625,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 mg/kg

SEX/DURATION :: female 13-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: SYNAET Synapse. (Wiley-Liss, Inc., 605 Third Ave., New York, NY USA 10158-0012) V.1- 1987- Volume(issue)/page/year: 15,198,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 17 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 19 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6179 No. of Facilities: 28 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1579 (estimated) No. of Female Employees: 1099 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Risk Phrases ]:
25

[ RIDADR ]:
UN 3249

[ RTECS ]:
SH5455000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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