Kirromycin

Names

[ Name ]:
Kirromycin

[Synonym ]:
antibiotic myc-8003

Biological Activity

[Description]:

Kirromycin (Mocimycin) is an antibiotic produced by Streptomyces ramocissimus. Kirromycin is a bacterial protein synthesis inhibitor that immobilizes elongation factor Tu (EF-Tu) on the elongating ribosome[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. H Wolf, et al. Kirromycin, an inhibitor of protein biosynthesis that acts on elongation factor Tu. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4910-4.

[2]. Lian N Olsthoorn-Tieleman, et al. Elongation factor Tu3 (EF-Tu3) from the kirromycin producer Streptomyces ramocissimus Is resistant to three classes of EF-Tu-specific inhibitors. J Bacteriol. 2007 May;189(9):3581-90.

Chemical & Physical Properties

[ Density]:
1.279g/cm3

[ Boiling Point ]:
936ºC at 760 mmHg

[ Molecular Formula ]:
C₄₃H₆₀N₂O₁₂

[ Molecular Weight ]:
796.94300

[ Flash Point ]:
519.9ºC

[ Exact Mass ]:
796.41500

[ PSA ]:
228.10000

[ LogP ]:
3.46570

[ Index of Refraction ]:
1.621

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QA2805000

CHEMICAL NAME :: Mocimycin

CAS REGISTRY NUMBER :: 50935-71-2

LAST UPDATED :: 199103

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C43-H60-N2-O12

MOLECULAR WEIGHT :: 797.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,109,1981

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

A signal relay between ribosomal protein S12 and elongation factor EF-Tu during decoding of mRNA.

RNA 15(2) , 208-14, (2009)

Codon recognition by aminoacyl-tRNA on the ribosome triggers a process leading to GTP hydrolysis by elongation factor Tu (EF-Tu) and release of aminoacyl-tRNA into the A site of the ribosome. The natu...

The phosphopantetheinyl transferase KirP activates the ACP and PCP domains of the kirromycin NRPS/PKS of Streptomyces collinus Tü 365.

FEMS Microbiol. Lett. 319(1) , 26-33, (2011)

The main steps in the biosynthesis of complex secondary metabolites such as the antibiotic kirromycin are catalyzed by modular polyketide synthases (PKS) and/or nonribosomal peptide synthetases (NRPS)...

Thermodynamic properties of nucleotide-free EF-Tu from Thermus thermophilus in the presence of low-molecular weight effectors of its GTPase activity.

Biochim. Biophys. Acta 1597(1) , 22-7, (2002)

The thermal transition of elongation factor EF-Tu from Thermus thermophilus in the presence of low-molecular weight effectors was studied by differential scanning calorimetry. The effectors of GTPase ...

Related Compounds

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