Saikogenin A

Names

[ Name ]:
Saikogenin A

[Synonym ]:
Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,16β)-
(3β,4α,16β)-Oleana-11,13(18)-diene-3,16,23,28-tetrol
saikogenin A
(3β,16β)-Oleana-11,13(18)-diene-3,16,23,28-tetrol

Biological Activity

[Description]:

Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase

Research Areas >> Metabolic Disease

Research Areas >> Inflammation/Immunology

Natural Products >> Terpenoids and Glycosides

[Target]

DPP-IV[1]

[In Vitro]

Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide[1].

[In Vivo]

Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation[2].

[References]

[1]. Pharmaceutical application of saikogenin A. CN107375300A.

[2]. Cheng JT, et al. Anti-inflammatory effect of Saikogenin A. Biochem Pharmacol. 1986 Aug 1;35(15):2483-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
607.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₈O₄

[ Molecular Weight ]:
472.700

[ Flash Point ]:
252.4±26.1 °C

[ Exact Mass ]:
472.355255

[ PSA ]:
80.92000

[ LogP ]:
5.38

[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C

[ Index of Refraction ]:
1.586

Saikogenin A

Names

Biological Activity

Chemical & Physical Properties

Related Compounds