Saikogenin A

Names

[ Name ]:
Saikogenin A

[Synonym ]:
Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,16β)-
(3β,4α,16β)-Oleana-11,13(18)-diene-3,16,23,28-tetrol
saikogenin A
(3β,16β)-Oleana-11,13(18)-diene-3,16,23,28-tetrol

Biological Activity

[Description]:

Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase

Research Areas >> Metabolic Disease

Research Areas >> Inflammation/Immunology

Natural Products >> Terpenoids and Glycosides

[Target]

DPP-IV[1]

[In Vitro]

Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide[1].

[In Vivo]

Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation[2].

[References]

[1]. Pharmaceutical application of saikogenin A. CN107375300A.

[2]. Cheng JT, et al. Anti-inflammatory effect of Saikogenin A. Biochem Pharmacol. 1986 Aug 1;35(15):2483-7.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
607.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₄₈O₄

[ Molecular Weight ]:
472.700

[ Flash Point ]:
252.4±26.1 °C

[ Exact Mass ]:
472.355255

[ PSA ]:
80.92000

[ LogP ]:
5.38

[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C

[ Index of Refraction ]:
1.586

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.