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Niranthin

Names

[ CAS No. ]:
50656-77-4

[ Name ]:
Niranthin

[Synonym ]:
1,3-Benzodioxole, 6-[(2R,3R)-4-(3,4-dimethoxyphenyl)-2,3-bis(methoxymethyl)butyl]-4-methoxy-
6-[(2R,3R)-3-(3,4-Dimethoxybenzyl)-4-methoxy-2-(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole

Biological Activity

[Description]:

Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis treatment[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Research Areas >> Infection
Research Areas >> Inflammation/Immunology

[Target]

Topoisomerase


[References]

[1]. Sayan Chowdhury, et al. The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice. EMBO Mol Med. 2012 Oct;4(10):1126-43.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
559.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H32O7

[ Molecular Weight ]:
432.507

[ Flash Point ]:
221.8±30.0 °C

[ Exact Mass ]:
432.214813

[ PSA ]:
64.61000

[ LogP ]:
4.40

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.534

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds