[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid

Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity[1].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

Metamizo (Methamizole; 100 mg/kg; i.p.; once; male Swiss albino mice) causes hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT) activity[1]. Metamizo (100 mg/kg; i.p.; once; male Swiss albino mice) causes a decrease in hepatic glutathione (GSH) contents[1]. Animal Model: Male Swiss albino mice (6 weeks old, 25-40 g)[1] Dosage: 100 mg/kg Administration: Intraperitoneal injection; once Result: Increased serum ALT level at 5 hours and the maximum serum ALT levels occurred at 5 hours. Animal Model: Male Swiss albino mice (6 weeks old, 25-40 g)[1] Dosage: 100 mg/kg Administration: Intraperitoneal injection; once Result: Induced reduction in hepatic glutathione (GSH) content in mice.