50567-35-6
50567-35-6 structure
- Name: [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulphonic acid
- Chemical Name: metamizole
- CAS Number: 50567-35-6
- Molecular Formula: C13H17N3O4S
- Molecular Weight: 311.35700
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2016-11-05 10:25:02
- Modify Date: 2025-08-27 13:29:56
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Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity[1].
| Name | metamizole |
|---|---|
| Synonyms |
Metamizol
UNII-934T64RMNJ Methamizole Novamine sulfone [(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-methylamino]methanesulfonic acid |
| Description | Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Metamizo (Methamizole; 100 mg/kg; i.p.; once; male Swiss albino mice) causes hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT) activity[1]. Metamizo (100 mg/kg; i.p.; once; male Swiss albino mice) causes a decrease in hepatic glutathione (GSH) contents[1]. Animal Model: Male Swiss albino mice (6 weeks old, 25-40 g)[1] Dosage: 100 mg/kg Administration: Intraperitoneal injection; once Result: Increased serum ALT level at 5 hours and the maximum serum ALT levels occurred at 5 hours. Animal Model: Male Swiss albino mice (6 weeks old, 25-40 g)[1] Dosage: 100 mg/kg Administration: Intraperitoneal injection; once Result: Induced reduction in hepatic glutathione (GSH) content in mice. |
| Density | 1.379g/cm3 |
|---|---|
| Molecular Formula | C13H17N3O4S |
| Molecular Weight | 311.35700 |
| Exact Mass | 311.09400 |
| PSA | 92.92000 |
| LogP | 1.84670 |
| Index of Refraction | 1.611 |
|
~%
50567-35-6 |
| Literature: Winthrop Chem.Co. Patent: US2128512 , 1935 ; Full Text Show Details I.G.Farbenind. Patent: DE617237 , 1934 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 22, p. 551 |
| Precursor 1 | |
|---|---|
| DownStream 4 | |
