2(5H)-Furanone
Names
[ CAS No. ]:
497-23-4
[ Name ]:
2(5H)-Furanone
[Synonym ]:
5-Hydrofuran-2-one
Furan-2(5H)-one
4-Hydroxycrotonic acid γ-lactone
2H-furan-5-one
2-Butenoic acid-γ-lactone
EINECS 207-839-3
T5OV EHJ
2-Butenoic acid γ-lactone
2(5H)-Furanone
MFCD00005376
2[5H]-furanone
4-Hydroxy-2-butenoic acid γ-lactone
γ-Crotonolactone
2-Buten-1,4-olide
2-Oxo-2,5-dihydrofuran
2-Butenoic acid, 4-hydroxy-, γ-lactone
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
203.7±0.0 °C at 760 mmHg
[ Melting Point ]:
4-5 °C(lit.)
[ Molecular Formula ]:
C4H4O2
[ Molecular Weight ]:
84.073
[ Flash Point ]:
101.1±0.0 °C
[ Exact Mass ]:
84.021126
[ PSA ]:
26.30000
[ LogP ]:
-0.84
[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.481
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LU3453000
- CHEMICAL NAME :
- 2(5H)-Furanone
- CAS REGISTRY NUMBER :
- 497-23-4
- BEILSTEIN REFERENCE NO. :
- 0383585
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C4-H4-O2
- MOLECULAR WEIGHT :
- 84.08
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1400 mg/kg
- SEX/DURATION :
- female 2 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - menstrual cycle changes or disorders
- REFERENCE :
- ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 123,571,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1400 mg/kg
- SEX/DURATION :
- female 2 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects Endocrine - changes in luteinizing hormone
- REFERENCE :
- ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 123,571,1990
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
LU3453000
[ Packaging Group ]:
I; II; III
[ HS Code ]:
29322980
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2932209090
[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Aquat. Toxicol. 149 , 116-25, (2014)
This study evaluated the potential adverse effects of butenolide, a promising antifouling compound, using the marine medaka (Oryzias melastigma), a model fish for marine ecotoxicology. The active ingr...
Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT).Aquat. Toxicol. 157 , 47-56, (2014)
SeaNine 211 with active ingredient of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) has been used as a "green" antifouling agent worldwide but has raised serious biosafety concerns in coastal en...
Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death.Toxicol. Lett. 222(1) , 64-71, (2013)
The alpha, beta-unsaturated lactones 2-furanone and 2-pyrone are part of the chemical structure of a variety of naturally occurring compounds (e.g., cardenolides, bufadienolides, acetogenins, coumarin...