HOMOQUINOLINIC ACID

Names

[ CAS No. ]:
490-75-5

[ Name ]:
HOMOQUINOLINIC ACID

[Synonym ]:
Homoquinolinate
Bromocriptine mesylate
Homoquinolinic acid
Tocris-0197

Biological Activity

[Description]:

Homoquinolinic acid is a non endogenous agonist of NMDAR2 receptor[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

Homoquinolinic acid (HQA，20 μM) 导致在第V层记录的事件频率显著增加[2]。 Homoquinolinic acid (HQA) 作用于突触前端，增强谷氨酸的释放[2]。

[References]

[1]. L P de Carvalho, et al. The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits. Neurochem Int. 1996 Apr;28(4):445-52.

[2]. G Woodhall, et al. NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. J Neurophysiol. 2001 Oct;86(4):1644-51.

Chemical & Physical Properties

[ Density]:
1.477g/cm3

[ Boiling Point ]:
437ºC at 760mmHg

[ Molecular Formula ]:
C₈H₇NO₄

[ Molecular Weight ]:
181.15

[ Flash Point ]:
218.1ºC

[ Exact Mass ]:
181.03800

[ PSA ]:
87.49000

[ LogP ]:
0.40690

[ Vapour Pressure ]:
2.07E-08mmHg at 25°C

[ Index of Refraction ]:
1.607

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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