VU 0650991

Names

[ Name ]:
VU 0650991

Biological Activity

[Description]:

GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Glucagon Receptor

[Target]

IC50: 650 nM (GLP-1R)[1].

[References]

[1]. Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core. J. Med. Chem. 19 Jan 2017.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₁ClF₆N₄O₂

[ Molecular Weight ]:
440.73

Related Compounds

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