Phillygenin

Names

[ CAS No. ]:
487-39-8

[ Name ]:
Phillygenin

[Synonym ]:
philligenin
sylvatesmin
Phillygenol
4-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenol
(+)-Phillygenin
Epipinoresinol methyl ether
Phenol, 4-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxy-
phylligenin
Phillygenin

Biological Activity

[Description]:

Phillygenin is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation.In vitro : 1) Phillygenin shows a greater inhibition on mouse B16 melanoma cells potential than vincristine.2) phillygenin had notable scavenging activity against DPPH, ABTS radicals, as well as potent reducing power in FRAP assay.In vivo: The reference for rat is 5.6 mg/m l ( i.v).

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

Natural Products >> Phenylpropanoids

[References]

[1]. Ye LH et al. Determination of phillygenin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Eur J Drug Metab Pharmacokinet, 2013 Sep, 38(3):201-7.

[2]. Song W et al. Interaction between phillygenin and human serum albumin based on spectroscopic and molecular docking. Spectrochim Acta A Mol Biomol Spectrosc, 2012 Jan, 85(1):120-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
534.9±50.0 °C at 760 mmHg

[ Melting Point ]:
133ºC

[ Molecular Formula ]:
C₂₁H₂₄O₆

[ Molecular Weight ]:
372.412

[ Flash Point ]:
277.3±30.1 °C

[ Exact Mass ]:
372.157288

[ PSA ]:
66.38000

[ LogP ]:
2.31

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.570

Related Compounds

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