NSC 21723

Names

[ CAS No. ]:
486-70-4

[ Name ]:
NSC 21723

[Synonym ]:
LUPININE
EINECS 207-638-0
MFCD00213431
(-)-LUPININE
OCTAHYDRO-1H-QUINOLIZIN-1-METHANOL
((1R,9aR)-Octahydro-1H-quinolizin-1-yl)methanol
LUPININ

Biological Activity

[Description]:

(-)-Lupinine is a quinolizidine alkaloid.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Stephen G Davies, et al. An efficient asymmetric synthesis of (-)-lupinine. Chem Commun (Camb). 2014 Aug 7;50(61):8309-11.

Chemical & Physical Properties

[ Density]:
1.04 g/cm3

[ Boiling Point ]:
160-164°C 4mm

[ Melting Point ]:
62-65°C

[ Molecular Formula ]:
C₁₀H₁₉NO

[ Molecular Weight ]:
169.26

[ Flash Point ]:
160-164°C/4mm

[ Exact Mass ]:
169.14700

[ PSA ]:
23.47000

[ LogP ]:
1.18110

[ Vapour Pressure ]:
0.000928mmHg at 25°C

[ Index of Refraction ]:
1.525

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OK5802000

CHEMICAL NAME :: Lupinine

CAS REGISTRY NUMBER :: 486-70-4

BEILSTEIN REFERENCE NO. :: 0080447

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H19-N-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 9(4),26,1946

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAGRAC Journal of Agricultural Research (Washington, DC). (Washington, DC) V.1-78, 1913-49. Discontinued. Volume(issue)/page/year: 32,51,1926

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S36/37

[ RIDADR ]:
1544

[ RTECS ]:
OK5802000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1