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1,2-Cyclohexylenedinitrilotetraacetic acid

Names

[ CAS No. ]:
482-54-2

[ Name ]:
1,2-Cyclohexylenedinitrilotetraacetic acid

[Synonym ]:
1,2-diaminocyclohexane-N,N,N',N'-tetraacetic acid hydrate
idranal iv
EINECS 207-582-7
complexoniv
chel600
1,2-diaminocyclohexane N,N,N',N'-tetraacetique acide
1,2-diaminocyclohexane-N,N,N'N'-tetraacetatic acid
octa
TitriplexIV
1,2-diaminocyclohexane-N,N,N',N'-tetraacetic acid
trans-cyclohexane-1,2-diamine-N,N,N',N'-tetra-acetate
komplexoniv
1,2-cyclohexanediamine-N,N,N',N'-tetraacetic acid
cgta

Biological Activity

[Description]:

1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[References]

[1]. Tandon SK, et al. Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study. Toxicology. 1975 Nov;5(2):237-41.  

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Boiling Point ]:
375.4ºC at 760 mmHg

[ Melting Point ]:
210-220°C

[ Molecular Formula ]:
C14H24N2O9

[ Molecular Weight ]:
364.34800

[ Exact Mass ]:
364.14800

[ PSA ]:
164.91000

[ Vapour Pressure ]:
1.9E-18mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AG5000000
CHEMICAL NAME :
Acetic acid, (1,2-cyclohexylenedinitrilo)tetra-
CAS REGISTRY NUMBER :
482-54-2
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C14-H22-N2-O8
MOLECULAR WEIGHT :
346.38
WISWESSER LINE NOTATION :
L6TJ AN1VQ1VQ BN1VQ1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
413 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - aggression Lungs, Thorax, or Respiration - chronic pulmonary edema
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 32,37,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7406 No. of Facilities: 223 (estimated) No. of Industries: 5 No. of Occupations: 4 No. of Employees: 1008 (estimated) No. of Female Employees: 155 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2922499990

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%


Related Compounds