tans-4-Hydroxy-D-proline methyl ester hydrochloride

Names

[ Name ]:
tans-4-Hydroxy-D-proline methyl ester hydrochloride

[Synonym ]:
Trans-4-hydroxy-L-proline methyl ester hydrochloride
1-Hydroxy-pentan-2-on
Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1)
1-hydroxy-pentan-2-one
Hydroxymethyl-propyl-keton
1-Hydroxy-2-pentanone
2-Pentanone,1-hydroxy
l-hydroxy-2-oxopentane
L-hydroxyproline methyl ester hydrochloride
L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1)
4S-hydroxy-1-pyrrolidine-2R-carboxylic acid methyl ester hydrochloride salt
1-hydroxy-2-oxopentane

Biological Activity

[Description]:

tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆H₁₂ClNO₃

[ Molecular Weight ]:
181.617

[ Exact Mass ]:
181.050568

[ PSA ]:
58.56000

[ LogP ]:
0.01300

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.