tans-4-Hydroxy-D-proline methyl ester hydrochloride
Modify Date: 2024-01-09 18:22:11
tans-4-Hydroxy-D-proline methyl ester hydrochloride structure
|
Common Name | tans-4-Hydroxy-D-proline methyl ester hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 481704-21-6 | Molecular Weight | 181.617 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H12ClNO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of tans-4-Hydroxy-D-proline methyl ester hydrochloridetans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
| Name | (2R,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylatehydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Molecular Formula | C6H12ClNO3 |
|---|---|
| Molecular Weight | 181.617 |
| Exact Mass | 181.050568 |
| PSA | 58.56000 |
| LogP | 0.01300 |
|
~85%
tans-4-Hydroxy-... CAS#:481704-21-6 |
| Literature: WO2003/104249 A1, ; Page 14 ; |
|
~%
tans-4-Hydroxy-... CAS#:481704-21-6 |
| Literature: WO2004/7444 A2, ; Page 141 ; |
|
~%
tans-4-Hydroxy-... CAS#:481704-21-6 |
| Literature: WO2013/49164 A1, ; Paragraph 838-839 ; |
| Trans-4-hydroxy-L-proline methyl ester hydrochloride |
| 1-Hydroxy-pentan-2-on |
| Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1) |
| 1-hydroxy-pentan-2-one |
| Hydroxymethyl-propyl-keton |
| 1-Hydroxy-2-pentanone |
| 2-Pentanone,1-hydroxy |
| l-hydroxy-2-oxopentane |
| L-hydroxyproline methyl ester hydrochloride |
| L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1) |
| 4S-hydroxy-1-pyrrolidine-2R-carboxylic acid methyl ester hydrochloride salt |
| 1-hydroxy-2-oxopentane |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: tans-4-Hydroxy-D-proline methyl ester hydrochloride
- Price: ￥2036.0/5g ￥276.0/250mg ￥676.0/1g ￥3406.0/10g
- Purity: 97.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: tans-4-Hydroxy-D-proline methyl ester hydrochloride
- Price: ￥Inquiry/10g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Lihua Yang
- DC Chemicals Limited
- China
- Product Name: tans-4-Hydroxy-D-proline methyl ester hydrochloride
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: (2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: H-Hyp-OMe.HCl
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
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