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tans-4-Hydroxy-D-proline hydrochloride

Names

[ CAS No. ]:
142347-81-7

[ Name ]:
tans-4-Hydroxy-D-proline hydrochloride

[Synonym ]:
(2R,4S)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
D-Proline, 1-hydroxy-, hydrochloride (1:1)
trans-4-Hydroxy-D-proline Hydrochloride
1-Hydroxy-D-proline hydrochloride (1:1)
(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid,hydrochloride
trans-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
(4S)-4-Hydroxy-D-proline hydrochloride (1:1)
D-Proline, 4-hydroxy-, (4S)-, hydrochloride (1:1)

Biological Activity

[Description]:

tans-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PR

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Chemical & Physical Properties

[ Boiling Point ]:
368.6ºC at 760mmHg

[ Molecular Formula ]:
C5H10ClNO3

[ Molecular Weight ]:
167.591

[ Flash Point ]:
176.7ºC

[ Exact Mass ]:
167.034927

[ PSA ]:
69.56000

[ Vapour Pressure ]:
6.22E-07mmHg at 25°C

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds