Hydroxymetronidazole

Names

[ Name ]:
Hydroxymetronidazole

[Synonym ]:
2-[2-(hydroxymethyl)-5-nitroimidazol-1-yl]ethanol

Biological Activity

[Description]:

Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Rodrigo H M M Granja, et al. Determination and confirmation of metronidazole, dimetridazole, ronidazole and their metabolites in bovine muscle by LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(6):970-6.

Chemical & Physical Properties

[ Density]:
1.61g/cm3

[ Boiling Point ]:
475.2ºC at 760mmHg

[ Melting Point ]:
118-121ºC

[ Molecular Formula ]:
C₆H₉N₃O₄

[ Molecular Weight ]:
187.15300

[ Flash Point ]:
241.2ºC

[ Exact Mass ]:
187.05900

[ PSA ]:
104.10000

[ Index of Refraction ]:
1.643

[ Storage condition ]:
-20?C Freezer

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI5568000

CHEMICAL NAME :: Imidazole-1-ethanol, 2-hydroxymethyl-5-nitro-

CAS REGISTRY NUMBER :: 4812-40-2

BEILSTEIN REFERENCE NO. :: 0883934

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H9-N3-O4

MOLECULAR WEIGHT :: 187.18

WISWESSER LINE NOTATION :: T5N CNJ A2Q B1Q ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Klebsiella pneumoniae

DOSE/DURATION :: 10 umol/L/20H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NI5568000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Development of a monoclonal antibody-based indirect competitive enzyme-linked immunosorbent assay for nitroimidazoles in edible animal tissues and feeds.

J. Pharm. Biomed. Anal. 120 , 84-91, (2016)

The misuse of nitroimidazoles (NDZs) can lead to NDZs residues in edible animal tissues, which would be harmful to consumer health. To quickly monitor NDZs residues in edible animal tissues and feed, ...

Multiresidue method for the simultaneous determination of veterinary medicinal products, feed additives and illegal dyes in eggs using liquid chromatography-tandem mass spectrometry.

Food Chem. 197 , 571-80, (2015)

A multiclass method was developed for the simultaneous determination of 120 analytes in fresh eggs. The method covers the analytes from the groups of tetracyclines (6), fluoroquinolones (11), sulphona...

Optimized liquid-chromatographic determination of metronidazole and its metabolites in plasma.

Clin. Chem. 30(5) , 784-7, (1984)

Metronidazole and its known metabolites in plasma can be rapidly separated by a "high-pressure" liquid-chromatographic method that can also be adapted for rapid determination of tinidazole. Samples de...