cis-ACPD

Names

[ Name ]:
cis-ACPD

[Synonym ]:
(1R,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid - (1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid (1:1)
1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1R,3R)-, compd. with (1S,3S)-1-amino-1,3-cyclopentanedicarboxylic acid (1:1)

Biological Activity

[Description]:

cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3 μM. And it is also a selective agonist of group II mGluR, with EC50s of 13 μM and 50 μM for mGluR2 and mGluR4, respectively[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

NMDA:3.3 μM (IC50)

mGluR2:13 μM (EC50)

mGluR4:50 μM (EC50)

[In Vitro]

cis-ACPD is a selective group II mGluR agonist, with EC50s of 13, 50, >300 and >300 μM for mGluR2, mGluR4, mGluR1 and mGluR5, respectively[2]. cis-ACPD (1-1000 µM; 60 min) stimulates hydrolysis of 3H-phosphoinositide[1].

[In Vivo]

cis-ACPD (1-1000 mg/kg; i.p.) produces dose-related convulsions in rats[1].

[References]

[1]. Schoepp DD, et, al. In vitro and in vivo pharmacology of trans- and cis-(+-)-1-amino-1,3-cyclopentanedicarboxylic acid: dissociation of metabotropic and ionotropic excitatory amino acid receptor effects. J Neurochem. 1991 May; 56(5):1789-96.

[2]. Conti P, et, al. Synthesis and pharmacology of 3-hydroxy-delta2-isoxazoline-cyclopentane analogues of glutamic acid. Farmaco. 2002 Nov; 57(11): 889-95.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₂N₂O₈

[ Molecular Weight ]:
346.333

[ Exact Mass ]:
346.137604

Related Compounds

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