Hexane-1,6-diyldiphosphonic acid

Names

[ Name ]:
Hexane-1,6-diyldiphosphonic acid

[Synonym ]:
1,6-hexylenediphosphonic acid
1,6-HEXYLENEBISPHOSPHONIC ACID
hexane-1,6-diylbisphosphonic acid
hexane-1,6-diyldiphosphonic acid
1,6-Hexanebisphosphonic acid
1,6-Diphosphono-hexan
1,6-hexanediphosphonic acid
hexane-1,6-bisphosphonic acid

Biological Activity

[Description]:

Hexane-1,6-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Melting Point ]:
206 °C

[ Molecular Formula ]:
C₆H₁₆O₆P₂

[ Molecular Weight ]:
246.13500

[ Exact Mass ]:
246.04200

[ PSA ]:
134.68000

[ LogP ]:
0.90220

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P337 + P313

[ Hazard Codes ]:
C

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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