(E)-10-Hydroxynortriptyline

Names

[ Name ]:
(E)-10-Hydroxynortriptyline

[Synonym ]:
E-10-hydroxynortriptyline
trans-10-Hydroxy Nortriptyline Maleate

Biological Activity

[Description]:

(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.

[2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

Chemical & Physical Properties

[ Density]:
1.164g/cm3

[ Boiling Point ]:
462.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₉H₂₁NO

[ Molecular Weight ]:
279.37600

[ Flash Point ]:
142.1ºC

[ Exact Mass ]:
279.16200

[ PSA ]:
32.26000

[ LogP ]:
3.70820

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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