Bullatine B

Names

[ CAS No. ]:
466-26-2

[ Name ]:
Bullatine B

[Synonym ]:
Xuan-Wu 3
Dideacetyldelphisine
Bullatine B
Aconitane-1,8,14-triol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-
20-Ethyl-6,16-dimethoxy-4-(methoxymethyl)aconitane-1,8,14-triol

Biological Activity

[Description]:

Neoline, the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Tanimura Y, et al. Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats.J Ethnopharmacol. 2019 Sep 15;241:111859.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
578.3±50.0 °C at 760 mmHg

[ Melting Point ]:
159-161 degºC

[ Molecular Formula ]:
C₂₄H₃₉NO₆

[ Molecular Weight ]:
437.570

[ Flash Point ]:
303.5±30.1 °C

[ Exact Mass ]:
437.277740

[ PSA ]:
91.62000

[ LogP ]:
-1.69

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.602

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR5569450

CHEMICAL NAME :: Aconitane-1,8,14-triol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1-alpha,6-alpha,14- alpha,16-beta)-

CAS REGISTRY NUMBER :: 466-26-2

LAST UPDATED :: 199412

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H39-N-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,180,1984

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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