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Delsoline

Names

[ CAS No. ]:
509-18-2

[ Name ]:
Delsoline

[Synonym ]:
Xuan-Wu 3
Bullatine-B
Dideacetyldelphisine
20-Ethyl-6,16-dimethoxy-4-(methoxymethyl)aconitane-1,8,14-triol
Delsoline
(1α,6β,14α,16β)-20-Ethyl-6,14,16-trimethoxy-4-(methoxymethyl)aconitane-1,7,8-triol
Aconitane-1,7,8-triol, 20-ethyl-6,14,16-trimethoxy-4-(methoxymethyl)-, (1α,6β,14α,16β)-

Biological Activity

[Description]:

Delsoline, a major alkaloid of Delphinium anthriscifolium Hance, has both a curare-like effect and a ganglion-blocking effect and is used to relieve muscle tension or hyperkinesia. D. anthriscifolium Hance has effects of dispelling wind and dampness, activating collaterals, and relieving pains and is used to treat rheumatism, hemiplegia, indigestion, and cough[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[References]

[1]. Shao L, et al. Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood. J Anal Methods Chem. 2018 Oct 11;2018:9412708.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
576.0±50.0 °C at 760 mmHg

[ Melting Point ]:
214ºC

[ Molecular Formula ]:
C25H41NO7

[ Molecular Weight ]:
467.595

[ Flash Point ]:
302.1±30.1 °C

[ Exact Mass ]:
467.288300

[ PSA ]:
100.85000

[ LogP ]:
-0.27

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.596

[ Storage condition ]:
2-8C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR5569490
CHEMICAL NAME :
Aconitane-1,7,8-triol, 20-ethyl-4-(methoxymethyl)-6,14,16-trimethoxy-, (1-alpha,6-beta,14-alpha,16-beta)-
CAS REGISTRY NUMBER :
509-18-2
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C25-H41-N-O7
MOLECULAR WEIGHT :
467.67

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
550 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

Safety Information

[ RTECS ]:
AR5569490

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream