Phenylpyrrolidone

Names

[ Name ]:
Phenylpyrrolidone

[Synonym ]:
1-Phenyl-2-pyrrolidinone
N-Phenylbutyrolactam
2-Pyrrolidinone, 1-phenyl-
N-(phenyl)-2-pyrrolidinone
EINECS 225-069-6
N-phenylpyrrolidinone
1-PHENYL-2-PYRROLIDONE
N-Phenylbutyrolactame
N-Phenyl-2-pyrrolidone
1-phenylpyrrolidin-2-one
N-PHENYL PYRROLIDONE
MFCD00003192
1-phenyl-azacyclopentan-2-one
N-Phenyl-2-pyrrolidinone
N-phenyl-pyrrolidin-2-one
Phenylpyrrolidone

Biological Activity

[Description]:

1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a phenyl analogue of GABA with sedative effect, decreasing the exploratory behavior of rats at 50-100 mg/kg (i.v.). 1-Phenyl-2-pyrrolidinone also has been proved to inhibit emotional reactions in dogs and cats. 1-Phenyl-2-pyrrolidinone induces decreases in the pressor reaction to emotional stress without accompanied by normalization of the function of baroreceptor reflexes[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Patkina N, et al. Some psychotropic effects of phenibut and phenylpyrrolidone. Trudy Volgogradskogo Gosudarstvennogo Meditsinskogo Instituta (1979), 31(3), 63-6.

[2]. Kovalev GV, et al. Effect of γ-aminobutyric acid derivatives on baroreceptor reflexes in nonanesthetized animals. Russian. 1980, (VINITI 1311-80), 10 pp.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
355.5±11.0 °C at 760 mmHg

[ Melting Point ]:
67-69 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₁NO

[ Molecular Weight ]:
161.20

[ Flash Point ]:
174.7±10.5 °C

[ Exact Mass ]:
161.084061

[ PSA ]:
20.31000

[ LogP ]:
1.39

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.578

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor.

Biochem. Biophys. Res. Commun. 313(4) , 992-7, (2004)

Blebbistatin is a novel 1-phenyl-2-pyrrolidinone derivative capable of inhibiting non-muscle myosin II activity with a high degree of specificity. We examined the effects of blebbistatin on pancreatic...

Related Compounds

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