DOCK2-IN-1

Names

[ Name ]:
DOCK2-IN-1

Biological Activity

[Description]:

DOCK2-IN-1 (compound 3), a CPYPP (HY-110100) analogue, is an inhibitor of DOCK2 as well (IC50=19.1 μM). DOCK2-IN-1 binds to DOCK2 DHR-2 domain in a reversible manner to inhibits its catalytic activity. DOCK2-IN-1 blocks the activation of both chemokine receptor- and antigen receptor-mediated Rac in lymphocytes. DOCK2-IN-1 significantly suppresses chemotactic response and T cell activation[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Target]

DOCK2

[References]

[1]. Nishikimi A, et al. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem Biol. 2012 Apr 20;19(4):488-97.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₁ClN₂O₂

[ Molecular Weight ]:
298.72

Related Compounds

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