4-Bromo-3-fluorotoluene
Names
[ CAS No. ]:
452-74-4
[ Name ]:
4-Bromo-3-fluorotoluene
[Synonym ]:
4-bromo-3-fluoro-toluene
Benzene, 1-bromo-2-fluoro-4-methyl-
1-Bromo-2-fluoro-4-methylbenzene
4-BroMo-3-fluorotoluene 5GR
3-Fluoro-4-bromo-toluone
4-Bromo-3-fluorotoluene
4-Bromo-3-fluoro-1-methylbenzene
1-Bromo-2-fluoro-4-methyl-benzene
4-Brom-3-fluor-toluol
2-fluoro-4-methylbromobenzene
3-FLUORO-4-BROMO-TOLUENE
4-Bromo-3-flurotoluene
MFCD00040940
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
185.7±20.0 °C at 760 mmHg
[ Molecular Formula ]:
C7H6BrF
[ Molecular Weight ]:
189.025
[ Flash Point ]:
68.6±16.6 °C
[ Exact Mass ]:
187.963684
[ LogP ]:
3.41
[ Vapour Pressure ]:
0.9±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.527
[ Storage condition ]:
Flammables area
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R10;R36/37/38
[ Safety Phrases ]:
S26-S37/39-S16
[ RIDADR ]:
UN 1993 3/PG 3
[ WGK Germany ]:
3
[ Packaging Group ]:
III
[ Hazard Class ]:
3
[ HS Code ]:
2903999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2903999090
[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
J. Med. Chem. 54 , 2293-306, (2011)
Poor blood-brain barrier penetration of nonsteroidal anti-inflammatory drugs (NSAIDs) has been blamed for the failure of the selective amyloid lowering agent (SALA) R-flurbiprofen in phase 3 clinical ...
Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.Bioorg. Med. Chem. Lett. 11(11) , 1411-5, (2001)
A series of aryloxy substituted piperazinones with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to have potent inhibitory activity ...
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.J. Med. Chem. 48 , 5705-20, (2005)
Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been recently described to selectively inhibit beta-amyloid(1)(-)(42) (Abeta42) secretion, the most toxic component of the senile plaque...