Prostaglandin F2β

Names

[ Name ]:
Prostaglandin F2β

[Synonym ]:
Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9β,11α,13E,15S)-
(5Z,9β,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid
9BETA, 11ALPHA-PROSTAGLANDIN F2
prostaglandin F2beta
Prostaglandin F2β

Biological Activity

[Description]:

(5R)-Dinoprost is a metabolite produced by cyclooxygenase metabolism of arachidonic acid. (5R)-Dinoprost (Prostaglandin F2β) induces dose-dependent release of hexose containing mucin[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Lamont JT, et, al. Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release. Gastroenterology. 1983 Feb;84(2):306-13.

[2]. Jang Y, et, al. Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception. J Neuroinflammation. 2020 Jan 22;17(1):30.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
531.0±50.0 °C at 760 mmHg

[ Melting Point ]:
105-106ºC

[ Molecular Formula ]:
C₂₀H₃₄O₅

[ Molecular Weight ]:
354.48

[ Flash Point ]:
289.0±26.6 °C

[ Exact Mass ]:
354.240631

[ PSA ]:
97.99000

[ LogP ]:
2.14

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.569

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ9658000

CHEMICAL NAME :: 5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)- , stereoisomer

CAS REGISTRY NUMBER :: 4510-16-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H34-O5

MOLECULAR WEIGHT :: 354.54

WISWESSER LINE NOTATION :: L5TJ AQ B2U4VQ C1U1YQ5 DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 10 mg/kg

SEX/DURATION :: female 19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - parturition

REFERENCE :: BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 36,188P,1969