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Yoda 1

Names

[ CAS No. ]:
448947-81-7

[ Name ]:
Yoda 1

[Synonym ]:
2-{5-[(2,6-Dichlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}pyrazine
2-[(2,6-dichlorobenzyl)thio]-5-pyrazin-2-yl-1,3,4-thiadiazole
MFCD00833175
Pyrazine, 2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-

Biological Activity

[Description]:

GlyT2-IN-1 is a glycine transporters GLYT2 inhibitor.Target: GLYT2The Glycine Transporter GlyT2 Controls the Dynamics of Synaptic Vesicle Refilling in Inhibitory Spinal Cord Neurons. GlyT2-IN-1 is a novel agonist of the mechanotransduction channel Piezo1, eliciting Ca2+ flux in Piezo1- but not vector-transfected cells.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT
Signaling Pathways >> Neuronal Signaling >> GlyT
Research Areas >> Cardiovascular Disease

[References]

[1]. Rousseau F, et al. The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. J Neurosci. 2008 Sep 24;28(39):9755-9768.


[Related Small Molecules]

Bitopertin | LY 2365109 hydrochloride | Sarcosine | Tilapertin

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
538.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H8Cl2N4S2

[ Molecular Weight ]:
355.265

[ Flash Point ]:
279.4±32.9 °C

[ Exact Mass ]:
353.956757

[ LogP ]:
4.89

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.714

Related Compounds