UNII:TL35μ1249

Names

[ Name ]:
UNII:TL35μ1249

[Synonym ]:
2,2'-diamino-1,1'-binaphthalene
UNII:TL35μ1249
1,1'-Binaphthalene-2,2'-diamine
1,1-BINAPHY1-2,2'-DIAMINE
(S)-1,1'-binaphthyl-2,2'-diamine
binaphthyldiamine
rac-1,1'-binaphthyl-2,2'-diamine
MFCD00145204
S(-)-DABN
2,2-DIAMINO-1,1'-BINAPHTHALENE
(R)-(+)-1,1'-binaphthyl-2,2'-diamine
R(+)-DABN
1,1'-Bi[naphthalene-2-amine]
1,1'-Binaphthyl-2,2'-diamine
(+)-2,2'-diamino-1,1-binaphthyl
1,1'-Bi(2-naphthalenamine)
[1,1'-Binaphthalene]-2,2'-diamine

Biological Activity

[Description]:

1,1'-Binaphthyl-2,2'-diamine is the inactive isomer of (S)-[1,1'-Binaphthalene]-2,2'-diamine (HY-W007978A), and can be used as an experimental control. (S)-[1,1'-Binaphthalene]-2,2'-diamine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Kettle JG, et al. Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C. J Med Chem. 2022 May 12;65(9):6940-6952.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
480.8±30.0 °C at 760 mmHg

[ Melting Point ]:
242-244ºC(lit.)

[ Molecular Formula ]:
C₂₀H₁₆N₂

[ Molecular Weight ]:
284.35

[ Flash Point ]:
293.9±24.0 °C

[ Exact Mass ]:
284.131348

[ PSA ]:
52.04000

[ LogP ]:
3.85

[ Appearance of Characters ]:
slightly beige

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.775

[ Water Solubility ]:
Insoluble in water

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU3090000

CHEMICAL NAME :: (1,1'-Binaphthalene)-2,2'-diamine

CAS REGISTRY NUMBER :: 4488-22-6

BEILSTEIN REFERENCE NO. :: 2138401

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H16-N2

MOLECULAR WEIGHT :: 284.38

WISWESSER LINE NOTATION :: L66J CZ B- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg/25W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8. Volume(issue)/page/year: 40,62,1940

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 mg/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8. Volume(issue)/page/year: 40,62,1940

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
36/37/38-41-22

[ Safety Phrases ]:
S26;S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DU3090000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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