2-Nitronaphthalene
Names
[ CAS No. ]:
581-89-5
[ Name ]:
2-Nitronaphthalene
[Synonym ]:
EINECS 209-474-5
MFCD00004055
2-Nitronaphthalene
Naphthalene, 2-nitro-
β-Nitronaphthalene
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
319.6±11.0 °C at 760 mmHg
[ Melting Point ]:
65-73 °C
[ Molecular Formula ]:
C10H7NO2
[ Molecular Weight ]:
173.168
[ Flash Point ]:
158.7±12.1 °C
[ Exact Mass ]:
173.047684
[ PSA ]:
45.82000
[ LogP ]:
3.18
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.671
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QJ9760000
- CHEMICAL NAME :
- Naphthalene, 2-nitro-
- CAS REGISTRY NUMBER :
- 581-89-5
- BEILSTEIN REFERENCE NO. :
- 2046354
- LAST UPDATED :
- 199801
- DATA ITEMS CITED :
- 26
- MOLECULAR FORMULA :
- C10-H7-N-O2
- MOLECULAR WEIGHT :
- 173.18
- WISWESSER LINE NOTATION :
- L66J CNW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4400 mg/kg
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2650 mg/kg
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - methemoglobinemia-carboxyhemoglobin
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2400 mg/kg/34/W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 340 gm/kg/5Y-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- REFERENCE :
- IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 19,642,1977 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,303,1989 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,303,1989 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 46,303,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.035 ppm (0.25 mg/m3);Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2-NITRONAPHTHALENE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
Safety Information
[ Symbol ]:
GHS02, GHS08, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H228-H350-H411
[ Precautionary Statements ]:
P201-P210-P273-P308 + P313
[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R45;R51/53
[ Safety Phrases ]:
53-45-61-60
[ RIDADR ]:
2538
[ WGK Germany ]:
3
[ RTECS ]:
QJ9760000
[ Packaging Group ]:
III
[ Hazard Class ]:
4.1
[ HS Code ]:
2904209090
Synthetic Route
Customs
[ HS Code ]: 2904209090
[ Summary ]:
2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
J. Appl. Toxicol. 6(1) , 13-20, (1986)
Male Swiss-Webster mice were exposed to naphthalene, 1-methyl-, 2-methyl-, 1-nitro- and 2-nitronaphthalene by intraperitoneal injection of peanut oil solutions over a dose range of 0.5-3.0 mmol kg-1 b...
Induction of LacZ mutations in Muta Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes.Mutat. Res. 608(1) , 88-96, (2006)
2,4-Diaminotoluene (2,4-DAT) is a liver carcinogen in rats and mice whereas 2,6-DAT is not. Both are genotoxic in vitro. Tests for mutations in transgenic mice, unscheduled DNA synthesis (UDS), DNA da...
1-nitronaphthalene.IARC Monogr. Eval. Carcinog. Risks Hum. 46 , 303-12, (1989)