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KIN-1400

Names

[ CAS No. ]:
446826-86-4

[ Name ]:
KIN-1400

[Synonym ]:
7-{(1,3-benzothiazol-2-ylamino)[4-(difluoromethoxy)phenyl]methyl}quinolin-8-ol
KIN1400
TCMDC-124379
8-Quinolinol, 7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]-
7-{(1,3-Benzothiazol-2-ylamino)[4-(difluoromethoxy)phenyl]methyl}-8-quinolinol
7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]-8-quinolinol
MFCD02655498

Biological Activity

[Description]:

A potent RIG-I-like receptor (RLR) agonist that triggers IRF3-dependent innate immune antiviral genes and IFN-β expression; shows antiviral activity against a broad range of RNA viruses, including dengue virus, and hepatitis C virus, as well as viruses of the families Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus), and Paramyxoviridae (respiratory syncytial virus, Nipah virus).

[References]

References 1. Pattabhi S, et al. J Virol. 2015 Dec 16;90(5):2372-87. View Related Products by Target RIG-I-like Receptor (RLR)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
651.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H17F2N3O2S

[ Molecular Weight ]:
449.473

[ Flash Point ]:
347.5±34.3 °C

[ Exact Mass ]:
449.100952

[ LogP ]:
5.48

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.727

Related Compounds