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KIN-281

Names

[ CAS No. ]:
74151-26-1

[ Name ]:
KIN-281

[Synonym ]:
4,6-Quinazolinediamine, N4-[4-(diethylamino)-1-methylbutyl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]-
N4-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)vinyl]quinazoline-4,6-diamine
N4-[5-(Diethylamino)-2-pentanyl]-2-[(E)-2-(2,4,6-trichlorophenyl)vinyl]-4,6-quinazolinediamine

Biological Activity

[Description]:

KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively; also inhibits BLK, CAMK Iiγ/δ, CAMK Iα, Tie2, BTK with IC50 of 1-10 uM; inhibit STAT3 activation, autophagy and cancer cell anchorage-independent growth in MDA-MB-231 and MDA-MB-468 breast cancer cells.

[References]

References 1. Zhou D, et al. Bioorg Med Chem. 2017 Jun 15;25(12):2995-3005. View Related Products by Target MELK

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
599.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H30Cl3N5

[ Molecular Weight ]:
506.898

[ Flash Point ]:
316.2±30.1 °C

[ Exact Mass ]:
505.156677

[ LogP ]:
5.26

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.676

Related Compounds