74151-26-1
74151-26-1 structure
- Name: KIN-281
- Chemical Name: N4-[5-(Diethylamino)-2-pentanyl]-2-[(E)-2-(2,4,6-trichlorophenyl)vinyl]-4,6-quinazolinediamine
- CAS Number: 74151-26-1
- Molecular Formula: C25H30Cl3N5
- Molecular Weight: 506.898
- Create Date: 2020-01-11 22:54:57
- Modify Date: 2024-01-18 20:18:47
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KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively; also inhibits BLK, CAMK Iiγ/δ, CAMK Iα, Tie2, BTK with IC50 of 1-10 uM; inhibit STAT3 activation, autophagy and cancer cell anchorage-independent growth in MDA-MB-231 and MDA-MB-468 breast cancer cells.
| Name | N4-[5-(Diethylamino)-2-pentanyl]-2-[(E)-2-(2,4,6-trichlorophenyl)vinyl]-4,6-quinazolinediamine |
|---|---|
| Synonyms |
4,6-Quinazolinediamine, N4-[4-(diethylamino)-1-methylbutyl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]-
N4-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)vinyl]quinazoline-4,6-diamine N4-[5-(Diethylamino)-2-pentanyl]-2-[(E)-2-(2,4,6-trichlorophenyl)vinyl]-4,6-quinazolinediamine |
| Description | KIN-281 is a small molecule that inhibits multiple kinases including MELK and the non-receptor tyrosine kinase BMX with IC50 of 1.4 and 1.9 uM, respectively; also inhibits BLK, CAMK Iiγ/δ, CAMK Iα, Tie2, BTK with IC50 of 1-10 uM; inhibit STAT3 activation, autophagy and cancer cell anchorage-independent growth in MDA-MB-231 and MDA-MB-468 breast cancer cells. |
|---|---|
| References | References 1. Zhou D, et al. Bioorg Med Chem. 2017 Jun 15;25(12):2995-3005. View Related Products by Target MELK |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 599.2±50.0 °C at 760 mmHg |
| Molecular Formula | C25H30Cl3N5 |
| Molecular Weight | 506.898 |
| Flash Point | 316.2±30.1 °C |
| Exact Mass | 505.156677 |
| LogP | 5.26 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.676 |