Oxirane,2-(phenylmethyl)-
Names
[ CAS No. ]:
4436-24-2
[ Name ]:
Oxirane,2-(phenylmethyl)-
[Synonym ]:
benzylethyleneoxide
2-benzyloxirane
3-phenylpropyleneoxide
allylbenzene oxide
Glycidylbenzene
benzyloxirane
(Phenylmethyl)oxirane
MFCD00074964
Chemical & Physical Properties
[ Density]:
1.094g/cm3
[ Boiling Point ]:
215ºC at 760mmHg
[ Molecular Formula ]:
C9H10O
[ Molecular Weight ]:
134.17500
[ Flash Point ]:
81.7ºC
[ Exact Mass ]:
134.07300
[ PSA ]:
12.53000
[ LogP ]:
1.62790
[ Index of Refraction ]:
n20/D 1.523(lit.)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DA0178000
- CHEMICAL NAME :
- Benzene, (2,3-epoxypropyl)-
- CAS REGISTRY NUMBER :
- 4436-24-2
- BEILSTEIN REFERENCE NO. :
- 0108023
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C9-H10-O
- MOLECULAR WEIGHT :
- 134.19
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 20 nmol/plate
- REFERENCE :
- CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 171,1041,1977
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
36/37/38
[ Safety Phrases ]:
26-36/37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
DA0178000
[ HS Code ]:
2910900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2910900090
[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
Articles
Toxicology 160 , 47-58, (2001)
The genotoxic potential of naturally occurring allylbenzene analogs, including safrole, eugenol, estragole, and others, has been examined in many studies over the past 30 years. It has been establishe...
Covalent binding to DNA in vitro of 2',3'-oxides derived from allylbenzene analogs.Drug Metab. Dispos. 24(9) , 1020-7, (1996)
Epoxidation at the allylic side chain is a major metabolic pathway for allylbenzene and its naturally occurring analogs safrole, estragole, and eugenol. We demonstrate herein that the epoxide metaboli...
Detoxication of the 2',3'-epoxide metabolites of allylbenzene and estragole. Conjugation with glutathione.Drug Metab. Dispos. 22(5) , 731-7, (1994)
The enzymatic detoxication in vitro of the 2',3'-epoxide derivatives of allylbenzene and estragole was examined, and the relative rates of enzymatic glutathione conjugation and epoxide hydrolysis were...