HSP90-IN-22

Names

[ Name ]:
HSP90-IN-22

[Synonym ]:
Benzamide, N-[2-(4-ethyl-1-piperazinyl)-4-methyl-6-quinolinyl]-3,4-dimethoxy-

Biological Activity

[Description]:

HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[References]

[1]. Jiang F, et al. Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors. Eur J Med Chem. 2017 Dec 1;141:1-14.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₀N₄O₃

[ Molecular Weight ]:
434.53

Related Compounds

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