3,3′-[6,6′-bi-1H-Benzimidazole]-2,2′-diylbis-benzenamine

Names

[ Name ]:
3,3′-[6,6′-bi-1H-Benzimidazole]-2,2′-diylbis-benzenamine

[Synonym ]:
Benzenamine, 3,3'-[6,6'-bi-1H-benzimidazole]-2,2'-diylbis-
3,3'-[6,6'-bi-1H-Benzimidazole]-2,2'-diylbis-benzenamine
MFCD01137750
3,3'-(1H,1'H-5,5'-Bibenzimidazole-2,2'-diyl)dianiline
DDRI-18

Biological Activity

[Description]:

DDRI-18 is a DNA damage response inhibitor that inhibits the non-homologous end-joining (NHEJ) DNA repair process. DDRI-18 is an effective chemosensitizing agent[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. D W Jun, et al. Characterization of DDRI-18 (3,3'-(1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response. Br J Pharmacol. 2012 Sep;167(1):141-50.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
835.8±75.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₆H₂₀N₆

[ Molecular Weight ]:
416.48

[ Flash Point ]:
503.4±24.3 °C

[ Exact Mass ]:
416.174957

[ LogP ]:
4.08

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.804

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H413

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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