VES
Names
[ CAS No. ]:
4345-03-3
[ Name ]:
VES
[Synonym ]:
a-Tocopheryl Succinate
Butanedioic Acid (2R-(2R*(4R*,8R*)))-mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester
a-Tocopheryl Acid Succinate
α-Tocopheryl acid succinate
(+)-α-Tocopheryl succinate
VES
EINECS 224-403-8
D-α-Tocopherol succinate
(+)-2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl Hydrogen Succinate
a-Tocopherol Acid Succinate
mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) butanedioate
Butanedioic acid Mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) Ester
d-alpha-Tocopherol succinate(E)
a-Tocopheryl Hydrogen Succinate
Butanedioic acid, mono[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester
4-Oxo-4-({(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl}oxy)butanoic acid
a-Tocopherol Hemisuccinate
Vitamin E Succinate
MFCD00072055
Covitol 1210
(+)-a-Tocopheryl Succinate
Biological Activity
[Description]:
[Related Catalog]:
[In Vitro]
[In Vivo]
[References]
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
625.8±55.0 °C at 760 mmHg
[ Melting Point ]:
~76 °C(lit.)
[ Molecular Formula ]:
C33H54O5
[ Molecular Weight ]:
530.779
[ Flash Point ]:
187.0±25.0 °C
[ Exact Mass ]:
530.397095
[ PSA ]:
72.83000
[ LogP ]:
11.88
[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C
[ Index of Refraction ]:
1.498
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EJ9984000
- CHEMICAL NAME :
- Butanedioic acid, mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimet hyltridecyl)-2H-1- benzopyran-6-yl) ester, (2R-(2R*(4R*,8R*)))-
- CAS REGISTRY NUMBER :
- 4345-03-3
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C33-H54-O5
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >7 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 25,273,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1129 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
EJ9984000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
AAPS PharmSciTech 16(2) , 444-54, (2015)
The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64)...
Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer.Biomaterials 64 , 10-20, (2015)
Metastasis is one of the major obstacles for the successful therapy of breast cancer. To inhibit the metastasis and growth of breast cancer simultaneously, a new docetaxel (DTX) loaded shrapnel nano d...
p66Shc longevity protein regulates the proliferation of human ovarian cancer cells.Mol. Carcinog. 54 , 618-31, (2015)
p66Shc functions as a longevity protein in murine and exhibits oxidase activity in regulating diverse biological activities. In this study, we investigated the role of p66Shc protein in regulating ova...