N6-(2-Hydroxyethyl)adenosine

Names

[ Name ]:
N6-(2-Hydroxyethyl)adenosine

[Synonym ]:
(2R,3R,4S,5R)-2-[6-(2-hydroxyethylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Biological Activity

[Description]:

N6-(2-Hydroxyethyl)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

[2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.88g/cm3

[ Boiling Point ]:
725.8ºC at 760 mmHg

[ Melting Point ]:
194-195ºC

[ Molecular Formula ]:
C₁₂H₁₇N₅O₅

[ Molecular Weight ]:
311.29

[ Flash Point ]:
392.7ºC

[ Exact Mass ]:
311.12300

[ PSA ]:
145.78000

[ Index of Refraction ]:
1.806

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Related Compounds

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