BRD32048

Names

[ Name ]:
BRD32048

[Synonym ]:
N-(4-Methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine
1,3,5-Triazine-2,4-diamine, N-(4-methoxyphenyl)-6-(1-piperidinylmethyl)-

Biological Activity

[Description]:

BRD32048 is a direct binder of ETV1 with a KD of 17.1 μM. BRD32048 modulates both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 inhibits ETV1 acetylation and promotes its degradation. BRD32048 acts as a top candidate ETV1 perturbagen[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. Marius S Pop, et al. A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein. Mol Cancer Ther. 2014 Jun;13(6):1492-502.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
545.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₂₂N₆O

[ Molecular Weight ]:
314.385

[ Flash Point ]:
283.6±32.9 °C

[ Exact Mass ]:
314.185516

[ PSA ]:
89.19000

[ LogP ]:
1.23

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.650

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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