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methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside

Names

[ CAS No. ]:
4330-34-1

[ Name ]:
methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside

[Synonym ]:
methyl 2-deoxy-3,5-di-O-p-toluoyl-D-ribofuranoside
1-o-methyl-2-deoxy-3,5-di(p-toluoyl)-erythro-pentafuranose
2-deoxy-1-O-methyl-3,5-di-O-p-toluoyl-D-ribofuranose
Methyl 2-Deoxy-3,5-di-O-p-toluoyl-D-erythro-pentoside
Methyl (5ξ)-2-deoxy-3-C-(2-methylbenzoyl)-6-(2-methylphenyl)-D-erythro-hexodialdo-1,4-furanoside
Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside
D-erythro-Hexodialdo-1,4-furanoside, methyl 2-deoxy-3-C-(2-methylbenzoyl)-6-(2-methylphenyl)-, (5ξ)-

Biological Activity

[Description]:

Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
581.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H24O6

[ Molecular Weight ]:
384.42

[ Flash Point ]:
202.4±23.6 °C

[ Exact Mass ]:
384.157288

[ PSA ]:
93.06000

[ LogP ]:
3.80

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Storage condition ]:
−20°C

Safety Information

[ WGK Germany ]:
3

[ HS Code ]:
29389090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds