p-toluoyl chloride
Names
[ CAS No. ]:
874-60-2
[ Name ]:
p-toluoyl chloride
[Synonym ]:
p-toluoyl chloride
p-Methylbenzoyl chloride
4-Methylbenzoyl chloride
4-Toluoyl chloride
Benzoyl chloride,4-methyl
4-Methylbenzoic acid chloride
p-Toluic acid chloride
p-Methyl-benzoylchloride
EINECS 212-864-8
MFCD00000696
4-methylbenzoic chloride
p-Toluyl chloride
4-methyl-benzoyl chloride
Benzoyl chloride, 4-methyl-
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
226.0±0.0 °C at 760 mmHg
[ Melting Point ]:
−4-−2 °C(lit.)
[ Molecular Formula ]:
C8H7ClO
[ Molecular Weight ]:
154.594
[ Flash Point ]:
82.2±0.0 °C
[ Exact Mass ]:
154.018539
[ PSA ]:
17.07000
[ LogP ]:
2.67
[ Vapour density ]:
5.33 (vs air)
[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.538
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XV1660000
- CHEMICAL NAME :
- p-Toluoyl chloride
- CAS REGISTRY NUMBER :
- 874-60-2
- BEILSTEIN REFERENCE NO. :
- 0471492
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C8-H7-Cl-O
- MOLECULAR WEIGHT :
- 154.60
- WISWESSER LINE NOTATION :
- GVR D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04246 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8312 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)
Safety Information
[ Symbol ]:
GHS05
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H314
[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive
[ Risk Phrases ]:
R34
[ Safety Phrases ]:
S26-S36/37/39-S45-S24/25
[ RIDADR ]:
UN 3265 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
XV1660000
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
2916399090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2916399090
[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Clin. Allergy 10(1) , 101-9, (1980)
Two antigens, both containing tolyl groups, were compared for ability to detect IgE antibodies in workers hypersensitive to toluene diisocyanate. One antigen, formed by reaction of p-tolyl isocyanate ...
Pyrazolone incorporating bipyridyl metallointercalators as effective DNA, protein and lung cancer targets: Synthesis, characterization and in vitro biocidal evaluation.Chem. Biol. Interact. 240 , 250-66, (2015)
Pyrazolone based metal complexes have strong bio-activity but the anti-cancer mechanism of these derivatives is not fully understood. In recent years, Cu(II) complexes have attracted the interest of r...
Benzoylation of toluene with p-toluoyl chloride over triflic acid functionalized mesoporous Zr-TMS catalyst. Landge SM, et al.J. Mol. Catal. A: Chem. 213(2) , 257-266, (2004)