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VU 0038882

Names

[ CAS No. ]:
429653-28-1

[ Name ]:
VU 0038882

[Synonym ]:
2-[5-(2-Furyl)-1H-pyrazol-3-yl]-1-naphthol
MFCD03016542
1-Naphthalenol, 2-[5-(2-furanyl)-1H-pyrazol-3-yl]-
2-(5-Furan-2-yl-1H-pyrazol-3-yl)-naphthalen-1-ol

Biological Activity

[Description]:

A small molecule activator of S. aureus HssRS (heme sensor system) that induces endogenous heme biosynthesis by perturbing central metabolism; prevents the emergence of antibiotic resistance, enhances phagocyte killing, and reduces S. aureus pathogenesis.

[References]

References 1. Mike LA, et al. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8206-11. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
525.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H12N2O2

[ Molecular Weight ]:
276.289

[ Flash Point ]:
271.4±28.7 °C

[ Exact Mass ]:
276.089874

[ LogP ]:
3.81

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.700

Related Compounds