Transketolase-IN-4

Names

[ CAS No. ]:
419547-73-2

[ Name ]:
Transketolase-IN-4

Biological Activity

[Description]:

Transketolase-IN-4 is a potent transketolase inhibitor (IC50=3.9 μM). Transketolase-IN-4 inhibits tumor cell proliferation of SW620, LS174T, and MIA PaCa-2. Transketolase-IN-4 is a possible Mycobacterium tuberculosis DXS inhibitor, with an IC50 value of 114.1 μM[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 3.9 μM (Transketolase)[1]; 114.1 μM (Mycobacterium tuberculosis DXS)[2]


[References]

[1]. Du MX, et al. Identification of novel small-molecule inhibitors for human transketolase by high-throughput screening with fluorescent intensity (FLINT) assay. J Biomol Screen. 2004 Aug;9(5):427-33.  

[2]. Mao J, et al. Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett. 2008 Oct 1;18(19):5320-3.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H14ClN3O

[ Molecular Weight ]:
335.78700

[ Exact Mass ]:
335.08300

[ PSA ]:
50.16000

[ LogP ]:
3.93380

Related Compounds