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(R)-Casopitant

Names

[ CAS No. ]:
414910-26-2

[ Name ]:
(R)-Casopitant

Biological Activity

[Description]:

(R)-Casopitant ((R)-GW679769) is the isomer of Casopitant (HY-14405). Casopitant is a NK(1)-receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[References]

[1]. Di Fabio, Romano, et al. Discovery and Biological Characterization of (2R,4S)-1'-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate. Journal of Medicinal Chemistry (2011), 54(4), 1071-1079.

[2]. Christina Ruhlmann, et al. Casopitant: a novel NK(1)-receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting. Ther Clin Risk Manag. 2009 Apr;5(2):375-84.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H35F7N4O2

[ Molecular Weight ]:
616.61

Related Compounds