414910-26-2

414910-26-2 structure

Name: (R)-Casopitant
Chemical Name: (R)-Casopitant
CAS Number: 414910-26-2
Molecular Formula: C₃₀H₃₅F₇N₄O₂
Molecular Weight: 616.61
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2023-02-01 19:52:57
Modify Date: 2024-01-31 13:07:48
(R)-Casopitant ((R)-GW679769) is the isomer of Casopitant (HY-14405). Casopitant is a NK(1)-receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting[1][2].

Name	(R)-Casopitant

Description	(R)-Casopitant ((R)-GW679769) is the isomer of Casopitant (HY-14405). Casopitant is a NK(1)-receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
References	[1]. Di Fabio, Romano, et al. Discovery and Biological Characterization of (2R,4S)-1'-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate. Journal of Medicinal Chemistry (2011), 54(4), 1071-1079. [2]. Christina Ruhlmann, et al. Casopitant: a novel NK(1)-receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting. Ther Clin Risk Manag. 2009 Apr;5(2):375-84.

Molecular Formula	C₃₀H₃₅F₇N₄O₂
Molecular Weight	616.61